Sisebenzisa amakhukhi ukwenza ngcono isipiliyoni sakho. Ngokuragela phambili nokuphequlula isayithi le, uvuma ukusebenzisa kwethu amakhukhi. Ilwazi elinabileko.
Ngokuchofoza "Vumela koke", uvuma ukugcinwa kwamakhukhi kudivayisi yakho ukwenza ngcono ukuzulazula kwesayithi, ukuhlaziya ukusetjenziswa kwesayithi, nokusekela ukunikelwa kwethu kokuqukethwe kwezesayensi kwamahhala, okuvulekileko. Ilwazi elinabileko.
Kghani ukuhlolwa komnthondo okulula kungathola ubulwele be-Alzheimer's esigabeni sokuthoma, kuvule indlela yokuthi kube namahlelo wokuhlola abantu abanengi? Irhubhululo elitjha le-Frontiers in Aging Neuroscience litjengisa lokhu. Abarhubhululi bahlola isiqhema esikhulu sezigulani ze-Alzheimer's ezinobunzima obuhlukahlukeneko nabantu abaphilileko ebegade bacabanga kuhle ukubona umehluko ema-biomarkers womnthondo.
Bathola bona i-formic acid emchameni litshwayo elizwakalako lokwehla kwengqondo begodu lingaveza amazinga wokuthoma wesifo se-Alzheimer. Iindlela ezikhona zokuhlola ubulwelwe be-Alzheimer ziyabiza, azilula, begodu angeze zahlolwa qobe. Lokhu kutjho bona inengi lezigulani litholwa kwaphela lokha nasele kuphuze khulu ukwelatjhwa okuphumelelako. Kodwana, ukuhlaziywa komnthondo okungahlaseliko, okungabiziko, nokulula kwe-formic acid kungaba ngilokho odokotela abakufunako ekuhlolweni kwangaphambilini.
"Ubulwelwe be-Alzheimer bulwelwe obungapheliko nobungapheliko, okutjho bona bungathuthuka begodu bube khona iminyaka eminengi ngaphambi kobana kuvele ukukhubazeka kokucabanga," kutjho abalobi. "Izigaba zokuthoma zesifo zenzeka ngaphambi kwesigaba sokulahlekelwa yingqondo okungabuyiselwa emuva, okulifasitela legolide lokungenelela nokwelatjhwa. Ngalokho-ke, ukuhlolwa okukhulu kwesigaba sokuthoma sesifo se-Alzheimer ebantwini abadala kuyatlhogeka."
Njeke, nangabe ukungenelela msinyana kuqakathekile, kubayini singanawo amahlelo wokuhlolela ubulwelwe be-Alzheimer obusesigabeni sokuthoma? Umraro ulele eendleleni zokuhlola odokotela abazisebenzisako njenganje. Lokhu kufaka hlangana i-positron emission tomography yengqondo, ebizako begodu ibeka iingulani emisebeni. Kuneemhloliso ze-biomarker ezingathola i-Alzheimer's, kodwana zitlhoga ukudonswa kweengazi okungenako nofana ukubhoboza i-lumbar ukuthola amanzi we-cerebrospinal, okungenzeka bona iingulani zibe zihlehlisa.
Kodwana, ukuhlolwa komnthondo akuhlaseli begodu kulula, okwenza bona kube kuhle ekuhlolweni kwabantu abanengi. Nanyana abarhubhululi bakhe bathola ama-biomarker womnthondo wobulwelwe be-Alzheimer, ayikho elungele ukuthola amazinga wokuthoma wobulwelwe, okutjho bona ifasitela legolide lokwelatjhwa msinyana lisatholakala.
Abarhubhululi abasemva kocwaningo olutjha sele bafunda nge-organic compound ebizwa nge-formaldehyde njenge-biomarker yomnthondo we-Alzheimer's disease. Nanyana kunjalo, kunendawo yokwenza ngcono ekutholeni amalwelwe msinyana. Kulesi sifundo sakamuva, badzimelele ku-formate, i-formaldehyde metabolite, ukubona bona isebenza ngcono na njenge-biomarker.
Inani labantu abangama-574 labamba iqhaza esifundweni, begodu abahlanganyeli bebabazinikeli abaphilileko ngokwengqondo namkha bebanezinga elihlukileko lokuragela phambili kwesifo, ukusuka ekuncipheni kwengqondo ukuya ekuguleni okupheleleko. Abarhubhululi bahlaziya umchamo namasampula weengazi zabahlanganyeli begodu benza ukuhlolwa kwengqondo.
Irhubhululo lithole bona amazinga we-formic acid emchameni bekaphakeme khulu kiwo woke amaqembu wobulwelwe be-Alzheimer begodu ahlotjaniswa nokwehla kwengqondo nayimadaniswa nabantu abaphilileko, okufaka hlangana isiqhema sokwehla kwengqondo ekuthomeni. Lokhu kuveza bona i-formic acid ingasebenza njenge-biomarker ebucayi yezigaba zokuthoma zesifo se-Alzheimer.
Okukarisako kukuthi, lokha abarhubhululi nabahlaziya amazinga we-urine formate ngokuhlanganiswa nama-biomarker weengazi ze-Alzheimer, bathola bona bangakwazi ukubikezela ngokunembileko isigaba sesifo isigulani esidlula kiso. Kodwana, irhubhululo elinabileko liyatlhogeka ukuzwisisa ukuhlobana hlangana kwesifo se-Alzheimer ne-formic acid.
"I-formic acid yomchamo itjengise ukuzwela okuhle khulu ekuhlolweni kwangaphambilini kwesifo se-Alzheimer," kutjho abalobi. "Ukuhlolwa kwe-biomarker yomchamo wobulwelwe be-Alzheimer kulula begodu akubizi begodu kufanele kufakwe ekuhlolweni kwepilo kwabantu abadala."
U-Wang, Y. nabanye. (2022) Ukubuyekezwa okuhlelekileko kwe-orinary formic acid njenge-biomarker etja engaba khona yesifo se-Alzheimer. Imikhawulo yesayensi yezinzwa yokuguga. doi.org/10.3389/fnagi.2022.1046066.
Amathegi: ukuguga, ubulwelwe be-Alzheimer, ama-biomarkers, iingazi, ubuqopho, amalwelwe angapheliko, amakhompawundi, ukulahlekelwa yingqondo, ukuhlola, odokotela, i-formaldehyde, i-neurology, i-positron emission tomography, irhubhululo, i-tomography, ukuhlaziywa komnthondo
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