Ngokuya kwemihlahlandlela eqinileko yokukhetha imithombo, sihlanganisa kwaphela iinkhungo zokurhubhulula zefundo, iindaba ezihloniphekileko, begodu, lapho zikhona khona, iimfundo zezokwelapha ezibuyekezwe ngontanga. Sibawa uqaphele bona iinomboro eziphakathi kwabakaki (1, 2, njll.) zikhonkwane eziqhafazwako eziya eemfundweni lezi.
Ilwazi elikuma-atikili wethu alihloselwe ukuthatha indawo yokukhulumisana nomuntu osebenzako wezamaphilo begodu alihloselwe ukusetjenziswa njengeseluleko sezokwelapha.
I-atikili le isekelwe ebufakazini bezesayensi, etlolwe ziingcwethi begodu ibuyekezwe lithimba lethu labahleli elibandulweko. Sibawa uqaphele bona iinomboro eziphakathi kwabakaki (1, 2, njll.) zijamele amakhonkco angachofozwako weemfundo zezokwelapha ezibuyekezwe ngontanga.
Isiqhema sethu sifaka hlangana iingcwethi zokudla ezitlolisiweko nezokudla, abafundisi bezamaphilo abaqinisekisweko, kanye nabososayensi abaqinisekisweko bezamamandla nokuzivocavoca, abaqeqetjhi bomuntu mathupha kanye nabososayensi bokuzivocavoca. Umnqopho wesiqhema sethu akusikurhubhulula okupheleleko kwaphela, kodwana nokungakhethi.
Ilwazi elikuma-atikili wethu alihloselwe ukuthatha indawo yokukhulumisana nomuntu osebenzako wezamaphilo begodu alihloselwe ukusetjenziswa njengeseluleko sezokwelapha.
Enye yezinto ezisetjenziswa khulu emithini neenthako namhlanjesi yi-magnesium stearate. Kuhlekuhle, kuzokuba budisi ukuthola isithasiselo emakethe namhlanjesi esinganawo—kungakhathaliseki bona sikhuluma ngesengezo se-magnesium, ama-enzayimu wokugaya ukudla, nofana esinye isithasiselo osikhethako—nanyana ungaliboni ibizo laso ngqo.
Ibizwa ngamanye amagama afana nokuthi "i-stearate yemirorho" nofana amanye amagama afana ne-"stearic acid", itholakala kizo zoke iindawo. Ngaphezu kokuba khona yoke indawo, i-magnesium stearate nayo ngenye yezinto eziphikisanako khulu ephasini lezithasiselo.
Ngezinye iindlela, lokhu kuyafana nekulumo-mpikiswano ngevithamini B17: ingabe yitjhefu nofana ikhambi lomdlavuza. Ngebhadi emphakathini, izazi zezamaphilo wemvelo, abarhubhululi beenkampani zezithasiselo, kanye nabasebenzi bezokwelapha kanengi baveza ubufakazi obuphikisanako ukusekela imibono yabo, begodu amaqiniso kubudisi khulu ukuwathola.
Kungcono ukuthatha indlela ephathekako eempikiswaneni ezinjalo begodu uqaphele ukuthatha ihlangothi lemibono edluleleko.
Umcijo uthi: Njengama-fillers amanengi nama-bulking agents, i-magnesium stearate ayikalungi lokha nayisetjenziswa khulu, kodwana ukuyisebenzisa akulimazi njengombana abanye batjho ngombana ivamise ukutholakala ngamanani amancani khulu.
I-magnesium stearate yi-magnesium salt ye-stearic acid. Ngokuyinhloko, yikhompawundi enemihlobo emibili ye-stearic acid ne-magnesium.
I-stearic acid yi-saturated fatty acid etholakala ekudleni okunengi, kufaka hlangana amafutha weenlwana newemirorho namafutha. I-cocoa ne-flaxseed ziimbonelo zokudla okune-stearic acid enengi.
Ngemva kobana i-magnesium stearate iphulwe ibuyele eengcenyeni zayo emzimbeni, amafutha wayo afana ne-stearic acid. I-magnesium stearate powder ivamise ukusetjenziswa njengesengezo sokudla, umthombo wokudla kanye nesithasiselo sezimonyo.
I-Magnesium stearate sisithako esisetjenziswa khulu ekwenzeni amathebulethi ngombana sisithambiso esisebenzako. Isetjenziswa godu emakhemikhali, emapuyereni, nokudla okunengi, okufakahlangana amaswidi amanengi, ama-gummies, amakhambi, iinongo, kanye neenthako zokubhaka.
Eyaziwa ngokuthi "i-ejenti yokugeleza," isiza ukurhabisa ikambiso yokukhiqiza ngokukhandela bona iinthako zinganamatheli emitjhini. Ingxube yepuyere evala pheze nanyana ngiyiphi imithi namkha ingxube yesengezo ngenani elincani.
Ingaphinde isetjenziswe njenge-emulsifier, enamathelayo, i-thickener, i-anti-caking agent, i-lubricant, i-ejenti yokukhupha kanye ne-foamer.
Akusebenzi kwaphela ekukhiqizeni ngokuvumela ukuthuthwa okubushelelezi emitjhinini ekhiqizako, kodwana kwenza bona amaphilisi kube lula ukuwagwinya nokukhambisa emgudwini wesisu. I-Magnesium stearate nayo iyisisetjenziswa esivamileko, okutjho bona isiza ukuthuthukisa umphumela wokwelapha weenthako ezisebenzako ezihlukahlukeneko begodu ikhuthaza ukumunywa nokuncibilika kwemithi.
Abanye bathi bayakwazi ukukhiqiza imithi nofana izengezo ngaphandle kwezinto ezisizako ezifana ne-magnesium stearate, okuphakamisa umbuzo wokobana kubayini zisetjenziswa lokha ezinye iindlela zemvelo zikhona. Kodwana lokhu kungenzeka kungabi njalo.
Eminye imikhiqizo sele yenziwa ngenye indlela yokusebenzisa i-magnesium stearate kusetjenziswa izinto zemvelo ezifana ne-ascorbyl palmitate, kodwana senza lokhu lapho kuzwakala khona ingasi ngombana siyitholi isayensi engakalungi. Kodwana, ezinye iindlela lezi azisebenzi ngaso soke isikhathi ngombana zineemfanelo ezihlukileko.
Njenganje akucaci bona ukufaka esikhundleni se-magnesium stearate kungenzeka na nofana kuyatlhogeka.
I-Magnesium stearate mhlamunye iphephile lokha nayidliwa ngobunengi obutholakala eensetjenzisweni zokudla nemithombo yokudla. Kuhlekuhle, kungakhathaliseki bona uyazi namkha awa, kungenzeka bona usebenzisa amavithamini amanengi, amafutha wekhokhonathi, amaqanda kanye nefesi qobe langa.
Njengamanye amaminerali ane-chelated (i-magnesium ascorbate, i-magnesium citrate, njll.), [ayinayo imiphumela emimbi ngombana yakhiwe ngamaminerali nama-esidi wokudla (i-stearic acid yemifino ehlanjululwe nge-magnesium salts). Iqukethe amakhompawundi angathathi ihlangothi azinzileko. .
Ngakelinye ihlangothi, i-National Institutes of Health (NIH) embikweni wayo nge-magnesium stearate yayelelisa bona i-magnesium enengi ingaphazamisa ukudluliswa kwemisipha begodu kurholele ekutheni kube buthakathaka nokwehla kokuziphendulela. Nanyana lokhu kungakavami khulu, i-National Institutes of Health (NIH) ibika:
Iinkulungwana zamacala wokutheleleka zenzeka qobe mnyaka, kodwana ukubonakaliswa okumbi akukavami. Ubuthi obukhulu buvame ukwenzeka ngemva kokufakwa ngaphakathi kwemithambo ema-awa amanengi (kanengi e-preeclampsia) begodu kungenzeka ngemva kokuthatha isikhathi eside, khulukhulu lokha nakunokuhluleka kweenso. Ubuthi obukhulu bubikwe ngemva kokungena okubukhali, kodwana kuyaqabukela.
Kodwana, umbiko awuzange uqinisekise woke umuntu. Ukuqala nje ku-Google kuzokutjengisa bona i-magnesium stearate ihlotjaniswa nemiphumela eminengi, enjengokuthi:
Ngombana ithanda amanzi ("ithanda amanzi"), kunemibiko yokuthi i-magnesium stearate inganciphisa izinga lokuncibilika kwemithi nezithasiselo emgudwini wesisu. Iimpawu zokuvikela ze-magnesium stearate zithinta ngqo ikghono lomzimba lokudosa amakhemikhali neemvundisi, okwenza bona umuthi nofana isengezo singasebenzi nangabe umzimba awukghoni ukuwuphula kuhle.
Ngakelinye ihlangothi, irhubhululo elenziwa yiYunivesithi ye-Maryland lithi i-magnesium stearate ayithinti inani lamakhemikhali akhutjhwa yi-propranolol hydrochloride, umuthi osetjenziselwa ukulawula ukubetha kwehliziyo nokuvuvuka kwama-bronchospasm, njeke ijaji isesephumile. .
Kuhlekuhle, abakhiqizi basebenzisa i-magnesium stearate ukwandisa ukuvumelana kwamakhemikhali begodu bakhuthaze ukumuncwa okufaneleko kwesidakamizwa ngokulibazisa ukuhlukana kokuqukethwe kuze kube yilapho ifinyelela emathunjini.
Amaseli we-T, ingcenye eqakathekileko yamasotja womzimba ahlasela amagciwane, awathintwa ngqo yi-magnesium stearate, kodwana athintwa yi-stearic acid, isithako esikhulu sezinto ezisizako ezijayelekileko.
Kwathoma ukuchazwa ngo-1990 kujenali ye-Immunology, lapho irhubhululo eliqakathekileko latjengisa bona amasotja womzimba athembele ku-T agandelelwa njani lokha nakune-stearic acid yodwa.
Esifundweni se-Japan esihlolisisa izinto ezijayelekileko, i-stearate ye-magnesium yemirorho yatholakala bona yiyo eqalisa ukwakheka kwe-formaldehyde. Kodwana, lokhu kungenzeka kungasabisi njengombana kubonakala, njengoba ubufakazi butjengisa bona i-formaldehyde itholakala ngokwemvelo eenthelweni ezinengi ezifretjhi, imirorho nemikhiqizo yeenlwana, okufakahlangana ama-apula, amabhanana, isipinatjhi, i-kale, inyama yenkomo ngitjho nekofi.
Ukukhulula ingqondo yakho, i-magnesium stearate ikhiqiza inani elincani le-formaldehyde kizo zoke iinsetjenziswa ezihloliweko: 0.3 nanograms ngegremu ye-magnesium stearate. Nawuqathanisa, ukudla amakhowe we-shiitake omisiweko kukhiqiza amamiligremu angaphezu kwama-406 we-formaldehyde ngekhilogremu edliwako.
Ngomnyaka ka-2011, iHlangano yezamaPhilo yePhasi yaveza umbiko ohlathulula bona amaqoqo amanengi we-magnesium stearate angcoliswe njani ngamakhemikhali angaba yingozi, kufaka hlangana i-bisphenol A, i-calcium hydroxide, i-dibenzoylmethane, i-irganox 1010 kanye ne-zeolite (sodium aluminum silicate).
Ngombana lesi sigameko esisodwa, angeze saphetha ngaphambi kwesikhathi bona abantu abathatha iinthako nemithi ene-magnesium stearate kufanele baqaphele ukusilaphazeka okunobuthi.
Abanye abantu bangaba namatshwayo wokungezwani komzimba ngemva kokudla imikhiqizo nofana ama-supplement ane-magnesium stearate, okungabanga ukurhuda nokuvuvuka emathunjini. Nangabe unokuphendula okumbi eentweni ezingezelelweko, kufanele ufunde amalebula wezithako ngokutjheja begodu wenze irhubhululo elincani ukuthola imikhiqizo engakakhiwa ngeenthako ezithandwako.
I-National Center for Biotechnology itusa bona umthamo we-2500 mg we-magnesium stearate ngekhilogremu yesisindo somzimba uthathwe njengophephileko. Kumuntu omdala onesisindo esingaba makhilogremu ali-150, lokhu kulingana nama-170,000 wamamiligremu ngelanga.
Nawucabanga ngemiphumela emimbi engaba khona ye-magnesium stearate, kuyasiza ukucabangela "ukuthembela emthamo". Ngamanye amagama, ngaphandle kokuthatha umuthi ngokweqileko ngemithanjeni malungana namalwelwe amambi, ukulimala kwe-magnesium stearate kutjengiswe kwaphela eemfundweni zelabhorethri lapho amagundwane aphakelwa khona umuthi owedluleleko kangangobana akekho umuntu ephasini ongadla kangaka.
Ngo-1980, ijenali i-Toxicology yabika imiphumela yocwaningo lapho amagundane ama-40 adliswa ukudla okune-0%, 5%, 10%, nofana 20% ye-magnesium stearate iinyanga ezintathu. Nakhu akutholileko:
Kufanele kuqashelwe bona inani le-stearic acid kanye ne-magnesium stearate esetjenziswa khulu emathebulethini mancani. I-stearic acid ivamise ukwenza i-0.5-10% ngesisindo sethebhulethi, ngesikhathi i-magnesium stearate ivamise ukwenza i-0.25-1.5% ngobunzima bethebhulethi. Ngalokho, ithebhulethi engu-500 mg ingaba ne-25 mg ye-stearic acid kanye ne-5 mg ye-magnesium stearate.
Ukunengi kwananyana yini kungaba yingozi begodu abantu bangafa ngokusela amanzi amanengi, angitjho? Lokhu kuqakathekile ukukukhumbula ngombana ukuze i-magnesium stearate ilimaze umuntu, kuzokutlhogeka bona athathe iinkulungwana zamaphilisi/amathebulethi ngelanga.